Search results for "Clinical staging"

showing 3 items of 3 documents

Staging, neurocognition and social functioning in bipolar disorder.

2018

Introduction: Bipolar disorder (BD) is associated with significant neurocognitive and functional impairment, which may progress across stages. The ‘latent stage' of BD remains understudied. This cross-sectional study assessed staging, neurocognition and social functioning among BD patients and their healthy siblings.Methods: Four groups were included: euthymic type I BD patients in the early (n = 25) and late (n = 23) stages, their healthy siblings (latent stage; n = 23) and healthy controls (n = 21). All 92 subjects underwent a comprehensive neuropsychological battery of processing speed, verbal learning/memory, visual memory, working memory, verbal fluency, executive cognition, and motor …

lcsh:RC435-571Bipolar disorderFenótiponeurocognitionVerbal learningfirst-degree relativesfunctioning03 medical and health sciencesNeurologia0302 clinical medicineVisual memorylcsh:Psychiatryclinical stagingmedicineMemóriaVerbal fluency testFirst-degree relativesFunctioningBipolar disorderNeurocognitionsiblingsOriginal ResearchPsychiatrybipolar disorderWorking memorybusiness.industrySiblingsTranstorno bipolarIrmãosCognitionmedicine.disease030227 psychiatryPsychiatry and Mental healthClinical stagingVerbal memorybusinessMalalties mentalsNeurocognitiveCogniçãoProgressão da doença030217 neurology & neurosurgeryClinical psychology
researchProduct

Clinical staging and serum cytokines in bipolar patients during euthymia

2017

Aims: Changes in serum cytokines and altered neutrophin concentration have been associated with bipolar disorder (BD). Our aim here was to analyze peripheral blood biomarkers according to the clinical stages of BD. Method: Euthymic BD-I patients were grouped according to their level of functioning in early-stage (n = 25) and late-stage (n = 23), and compared to healthy siblings (n = 23) and genetically unrelated healthy controls (n = 21). Neurotrophin (neurotrophin-3 and BDNF) concentration and biomarkers of inflammation, including cytokines (IL-6, IL-10 and TNF-alpha), leukocytes count and acute phase proteins, were measured. Results: IL-10 concentration was significantly increased in earl…

AdultMaleBipolar DisorderBipolar disorderInflammationNeurotrophinsYoung Adult03 medical and health sciences0302 clinical medicineNeurotrophin 3medicineLeukocytesHumansNerve Growth FactorsBipolar disorderBiological PsychiatryPharmacologyInflammationbiologyInterleukin-6Tumor Necrosis Factor-alphabusiness.industryBrain-Derived Neurotrophic FactorSiblingsAcute-phase proteinMiddle Agedmedicine.diseaseBlood Cell CountInterleukin-10030227 psychiatryPeripheralAffectSerum cytokineClinical stagingCase-Control StudiesImmunologybiology.proteinBiomarker (medicine)CytokinesFemaleTumor necrosis factor alphamedicine.symptombusinessBiomarkers030217 neurology & neurosurgeryAcute-Phase ProteinsNeurotrophin
researchProduct

Elective partial nephrectomy is equivalent to radical nephrectomy in patients with clinical T1 renal cell carcinoma: results of a retrospective, comp…

2012

Study Type - Therapy (cohort) Level of Evidence 2b What's known on the subject? and What does the study add? Few studies supported the expanded indications for nephron-sparing surgery (NSS) in selected patients with 4.1 cm renal tumours in the size range (T1b). However, all these comparative studies included both imperative and elective partial nephrectomy and patient selection for analysis was based on pathological stage (pT1) and not on clinical stage (cT1). Patients with clinically organ-confined RCC (cT1) who are candidates for elective PN have a limited risk of clinical understaging. NSS is not associated with an increased risk of recurrence and cancer-specific mortality both in cT1a a…

Malerenal cell carcinomapartial nephrectomyrenal cancerNephrectomymethodsElectiveclinical staging; nephron-sparing surgery; partial nephrectomy; radical nephrectomy; renal cancernephrectomyclinical stagingHumansCarcinoma Renal CellSurgical ProceduresElective Surgical ProcedureCarcinomanephron-sparing surgeryRenal CellElective partial nephrectomy is equivalent to radical nephrectomy in patients with clinical T1 renal cell carcinomaKidney NeoplasmMiddle AgedKidney NeoplasmsSurvival Ratemortality/pathology/surgeryElective Surgical Proceduresnephrectomy; renal cell carcinoma; nephron-sparing surgeryFemaleCarcinoma; Renal Cell; mortality/pathology/surgery Female Humans Kidney Neoplasms; mortality/pathology/surgery Male Middle Aged Nephrectomy; methods Surgical Procedures; Elective Survival RateHumanradical nephrectomy
researchProduct